• Broker Alex Gonzalez 9729742670
  • Broker Michael Gonzalez 2146645655

Main Professional Building 541 W Main St 800 - 7,513 SF of Space Available in Lewisville, TX 75057

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HIGHLIGHTS

  • $18 PSF + NNN (estimated $5.05)
  • 2nd-gen medical suites from 1,400 SF to 2,500 SF
  • Near historic Old Town Lewisville
  • Move-in ready 800 SF former laboratory
  • Across from Medical City Lewisville
  • 22,914 VPD at W Main & Ray Dunning Blvd

ALL AVAILABLE SPACES(5)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 1st Floor, Ste 101
  • 1,413 SF
  • 3-5 Years
  • $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,120 /MO $25,434 /YR
  • Medical
  • -
  • Now
541 W Main St, Lewisville, TX for lease Floor Plan- Image 1 of 1
Floor Plan

2nd gen medical space across from Medical City Lewisville 2 exam rooms, 2 offices, reception, lab/nurse station, waiting room, 2 restrooms. Available immediately

  • Lease rate does not include utilities, property expenses or building services
  • 541 W Main St Flyer 2025
  • 1st Floor, Ste 140 G/H
  • 1,400 SF
  • 3-5 Years
  • $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR
  • Office/Medical
  • -
  • Now
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1,400 SF available for pharmacy and/or office use.

  • Lease rate does not include utilities, property expenses or building services
  • 1st Floor, Ste 140B
  • 1,400 SF
  • Negotiable
  • $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR
  • Office/Medical
  • -
  • August 31, 2025
  • Lease rate does not include utilities, property expenses or building services
  • 1st Floor, Ste 150
  • 2,500 SF
  • Negotiable
  • $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $3,750 /MO $45,000 /YR
  • Medical
  • Full Build-Out
  • September 01, 2025
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2nd gen medical space coming available 8/31/2025. 6 Exam Rooms 1 Treatment/Procedure Room 2 Offices Reception Waiting Room 2 Restrooms

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Medical Space
  • 1st Floor, Ste 160
  • 800 SF
  • 3-5 Years
  • $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $1,200 /MO $14,400 /YR
  • Office/Medical
  • -
  • Now
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541 W Main St, Lewisville, TX for lease Interior Photo- Image 1 of 5
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541 W Main St, Lewisville, TX for lease Floor Plan- Image 5 of 5
Floor Plan

800 SF former laboratory available

  • Lease rate does not include utilities, property expenses or building services
Space Size Term Rental Rate Space Use Condition Available
1st Floor, Ste 101 1,413 SF 3-5 Years $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,120 /MO $25,434 /YR Medical - Now
1st Floor, Ste 140 G/H 1,400 SF 3-5 Years $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR Office/Medical - Now
1st Floor, Ste 140B 1,400 SF Negotiable $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR Office/Medical - August 31, 2025
1st Floor, Ste 150 2,500 SF Negotiable $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $3,750 /MO $45,000 /YR Medical Full Build-Out September 01, 2025
1st Floor, Ste 160 800 SF 3-5 Years $18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $1,200 /MO $14,400 /YR Office/Medical - Now

1st Floor, Ste 101

Size
1,413 SF
Term
3-5 Years
Rental Rate
$18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,120 /MO $25,434 /YR
Space Use
Medical
Condition
-
Available
Now

1st Floor, Ste 140 G/H

Size
1,400 SF
Term
3-5 Years
Rental Rate
$18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR
Space Use
Office/Medical
Condition
-
Available
Now

1st Floor, Ste 140B

Size
1,400 SF
Term
Negotiable
Rental Rate
$18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $2,100 /MO $25,200 /YR
Space Use
Office/Medical
Condition
-
Available
August 31, 2025

1st Floor, Ste 150

Size
2,500 SF
Term
Negotiable
Rental Rate
$18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $3,750 /MO $45,000 /YR
Space Use
Medical
Condition
Full Build-Out
Available
September 01, 2025

1st Floor, Ste 160

Size
800 SF
Term
3-5 Years
Rental Rate
$18.00 /SF/YR $1.50 /SF/MO $193.75 /m²/YR $16.15 /m²/MO $1,200 /MO $14,400 /YR
Space Use
Office/Medical
Condition
-
Available
Now
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541 W Main St, Lewisville, TX for lease Floor Plan- Image 1 of 1
Suite 101 Floorplan

1st Floor, Ste 101

541 W Main St, Lewisville, TX for lease Floor Plan- Image 1 of 1
Floor Plan
Size 1,413 SF
Term 3-5 Years
Rental Rate $18.00 /SF/YR
Space Use Medical
Condition -
Available Now

2nd gen medical space across from Medical City Lewisville 2 exam rooms, 2 offices, reception, lab/nurse station, waiting room, 2 restrooms. Available immediately

  • Lease rate does not include utilities, property expenses or building services
  • 541 W Main St Flyer 2025
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541 W Main St, Lewisville, TX for lease Floor Plan- Image 1 of 8
Suite 140A Floorplan
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1st Floor, Ste 140 G/H

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541 W Main St, Lewisville, TX for lease Floor Plan- Image 1 of 8
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Size 1,400 SF
Term 3-5 Years
Rental Rate $18.00 /SF/YR
Space Use Office/Medical
Condition -
Available Now

1,400 SF available for pharmacy and/or office use.

  • Lease rate does not include utilities, property expenses or building services

1st Floor, Ste 140B

Size 1,400 SF
Term Negotiable
Rental Rate $18.00 /SF/YR
Space Use Office/Medical
Condition -
Available August 31, 2025

  • Lease rate does not include utilities, property expenses or building services
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Suite 150 Floorplan
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1st Floor, Ste 150

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Size 2,500 SF
Term Negotiable
Rental Rate $18.00 /SF/YR
Space Use Medical
Condition Full Build-Out
Available September 01, 2025

2nd gen medical space coming available 8/31/2025. 6 Exam Rooms 1 Treatment/Procedure Room 2 Offices Reception Waiting Room 2 Restrooms

  • Lease rate does not include utilities, property expenses or building services
  • Fully Built-Out as Standard Medical Space
1 of 5
VIDEOS
3D TOUR
PHOTOS
STREET VIEW STREET
MAP
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541 W Main St, Lewisville, TX for lease Interior Photo- Image 1 of 5
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Suite 106

1st Floor, Ste 160

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541 W Main St, Lewisville, TX for lease Floor Plan- Image 5 of 5
Floor Plan
Size 800 SF
Term 3-5 Years
Rental Rate $18.00 /SF/YR
Space Use Office/Medical
Condition -
Available Now

800 SF former laboratory available

  • Lease rate does not include utilities, property expenses or building services

PROPERTY OVERVIEW

Now available for lease, this well-located medical office opportunity in the heart of Lewisville offers a range of ready-to-occupy medical suites ideal for pharmacy, lab, and general healthcare practices. Situated directly across from Medical City Lewisville and just minutes from historic Old Town Lewisville, this property benefits from excellent visibility and access along W Main Street. With flexible suite sizes ranging from 800 SF to 2,500 SF, and competitive lease terms, this location provides both affordability and immediate usability for growing healthcare operations.

PROPERTY FACTS

Building Type
Office
Year Built
1985
Building Height
1 Story
Building Size
10,554 SF
Building Class
C
Typical Floor Size
10,554 SF
Parking
40 Surface Parking Spaces

ATTACHMENTS

541 W Main St Flyer 2025

LINKS

  • See more Structure Commercial listings here
  • Alex Gonzalez Bio
  • Michael Gonzalez Bio

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ADDITIONAL PHOTOS

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  • Listing ID: 31082390

  • Date on Market: 6/5/2025

  • Last Updated: 6/16/2025

  • Address: 541 W Main St, Lewisville, TX 75057